Multi-class texture analysis in colorectal cancer histology
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Automatic recognition of different tissue types in histological images is an essential part in the digital pathology toolbox. Texture analysis is commonly used to address this problem; mainly in the context of estimating the tumour/stroma ratio on histological samples. However, although histological images typically contain more than two tissue types, only few studies have addressed the multi-class problem. For colorectal cancer, one of the most prevalent tumour types, there are in fact no published results on multiclass texture separation. In this paper we present a new dataset of 5,000 histological images of human colorectal cancer including eight different types of tissue. We used this set to assess the classification performance of a wide range of texture descriptors and classifiers. As a result, we found an optimal classification strategy that markedly outperformed traditional methods, improving the state of the art for tumour-stroma separation from 96.9% to 98.6% accuracy and setting a new standard for multiclass tissue separation (87.4% accuracy for eight classes). We make our dataset of histological images publicly available under a Creative Commons license and encourage other researchers to use it as a benchmark for their studies.
Details
Original language | English |
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Article number | 27988 |
Journal | Scientific reports |
Volume | 6 |
Publication status | Published - 16 Jun 2016 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 27306927 |
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