Multi-class texture analysis in colorectal cancer histology

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Jakob Nikolas Kather - , Heidelberg University  (Author)
  • Cleo Aron Weis - , Heidelberg University  (Author)
  • Francesco Bianconi - , University of Perugia (Author)
  • Susanne M. Melchers - , Heidelberg University  (Author)
  • Lothar R. Schad - , Heidelberg University  (Author)
  • Timo Gaiser - , Heidelberg University  (Author)
  • Alexander Marx - , Heidelberg University  (Author)
  • Frank Gerrit Zöllner - , Heidelberg University  (Author)

Abstract

Automatic recognition of different tissue types in histological images is an essential part in the digital pathology toolbox. Texture analysis is commonly used to address this problem; mainly in the context of estimating the tumour/stroma ratio on histological samples. However, although histological images typically contain more than two tissue types, only few studies have addressed the multi-class problem. For colorectal cancer, one of the most prevalent tumour types, there are in fact no published results on multiclass texture separation. In this paper we present a new dataset of 5,000 histological images of human colorectal cancer including eight different types of tissue. We used this set to assess the classification performance of a wide range of texture descriptors and classifiers. As a result, we found an optimal classification strategy that markedly outperformed traditional methods, improving the state of the art for tumour-stroma separation from 96.9% to 98.6% accuracy and setting a new standard for multiclass tissue separation (87.4% accuracy for eight classes). We make our dataset of histological images publicly available under a Creative Commons license and encourage other researchers to use it as a benchmark for their studies.

Details

Original languageEnglish
Article number27988
JournalScientific reports
Volume6
Publication statusPublished - 16 Jun 2016
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 27306927

Keywords

Sustainable Development Goals

ASJC Scopus subject areas