Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)

Research output: Contribution to journalResearch articleContributed

Contributors

  • Linda A J Hendricks - , Radboud University Medical Center (Author)
  • Katja C J Verbeek - , Radboud University Medical Center (Author)
  • Janneke H M Schuurs-Hoeijmakers - , Radboud University Medical Center (Author)
  • Arjen R Mensenkamp - , Radboud University Medical Center (Author)
  • Hilde Brems - , KU Leuven (Author)
  • Robin de Putter - , Ghent University Hospital (Author)
  • Violetta C Anastasiadou - , Archbishop Makarios III Hospital (Author)
  • Marie-Charlotte Villy - , Institut Curie (Author)
  • Arne Jahn - , Institute of Clinical Genetics, German Cancer Consortium (Partner: DKTK, DKFZ), National Center for Tumor Diseases (Partners: UKD, MFD, HZDR, DKFZ) (Author)
  • Verena Steinke-Lange - , Arbeitsgruppe Erbliche Gastrointestinale Tumore, Medizinische Klinik und Poliklinik IV-Campus Innenstadt, Klinikum der Universität München, 81377 Munich, Germany. (Author)
  • Margherita Baldassarri - , Genetica Medica, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy. (Author)
  • Arvids Irmejs - , Paula Stradina Clinical University Hospital (Author)
  • Mirjam M de Jong - , University Medical Center Groningen (Author)
  • Thera P Links - , University Medical Center Groningen (Author)
  • Edward M Leter - , Maastricht University Medical Centre (UMC+) (Author)
  • Daniëlle G M Bosch - , Erasmus University Medical Center (Author)
  • Hildegunn Høberg-Vetti - , Haukeland universitets­sjukehus (Author)
  • Marianne Tveit Haavind - , Haukeland universitets­sjukehus (Author)
  • Kjersti Jørgensen - , Oslo University Hospital (Author)
  • Lovise Mæhle - , Oslo University Hospital (Author)
  • Ana Blatnik - , Institute of Oncology Ljubljana (Author)
  • Joan Brunet - , Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL) (Author)
  • Esther Darder - , Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL) (Author)
  • Emma Tham - , Karolinska University Hospital (Author)
  • Nicoline Hoogerbrugge - , Radboud University Medical Center (Author)
  • Janet R Vos - , Radboud University Medical Center (Author)

Abstract

Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020-March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0-1 times/week physical activity than ≥2 times (ORtotal-adj = 0.9 (95%CI 0.3-2.6); consumed daily about 1.2-1.8 times more often ≥1 than 0-1 glasses of alcohol (ORtotal-adj = 1.2 (95%CI 0.4-4.0); ORnon-breastcancer-index-adj = 1.8 (95%CI 0.4-6.9); were about 1.04-1.3 times more often smokers than non-smokers (ORtotal-adj = 1.04 (95%CI 0.4-2.8); ORnon-breastcancer-index-adj = 1.3 (95%CI 0.4-4.2)); and overweight or obesity (72%) was about 1.02-1.3 times less common (ORtotal-adj = 0.98 (95%CI 0.4-2.6); ORnon-breastcancer-index-adj = 0.8 (95%CI 0.3-2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients' breast cancer risk is important.

Details

Original languageEnglish
Article number953
JournalCancers
Volume16
Issue number5
Publication statusPublished - 27 Feb 2024
Peer-reviewedNo

External IDs

PubMedCentral PMC10930780
Scopus 85187482396

Keywords

Sustainable Development Goals