Isolation of 3' -O-acetylchloramphenicol: a possible intermediate in chloramphenicol biosynthesis

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Frank Gross - , Chair of Biochemistry, Dalhousie University (Author)
  • Elizabeth A Lewis - , Dalhousie University (Author)
  • Mahmood Piraee - , Dalhousie University (Author)
  • Karl-Heinz van Pee - , Chair of Biochemistry (Author)
  • Leo C Vining - , Dalhousie University (Author)
  • Robert L White - , Dalhousie University (Author)

Abstract

3' -O-acetylchloramphenicol, commonly formed from chloramphenicol by resistant bacteria, has been isolated from the antibiotic-producing organism. Biosynthetic experiments suggest that it is a protected intermediate in chloramphenicol biosynthesis, implicating acetylation as a self-resistance mechanism in the producing organism.

Details

Original languageEnglish
Pages (from-to)283-6
Number of pages4
JournalBioorganic & medicinal chemistry letters : a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines
Volume12
Issue number3
Publication statusPublished - 11 Feb 2002
Peer-reviewedYes

External IDs

Scopus 0037060652

Keywords

Keywords

  • Acetylation, Anti-Bacterial Agents/biosynthesis, Chloramphenicol/analogs & derivatives, Chromatography, High Pressure Liquid, Hydrolysis, Magnetic Resonance Spectroscopy, Streptomyces/chemistry