Isolation of 3' -O-acetylchloramphenicol: a possible intermediate in chloramphenicol biosynthesis
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
3' -O-acetylchloramphenicol, commonly formed from chloramphenicol by resistant bacteria, has been isolated from the antibiotic-producing organism. Biosynthetic experiments suggest that it is a protected intermediate in chloramphenicol biosynthesis, implicating acetylation as a self-resistance mechanism in the producing organism.
Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 283-6 |
| Seitenumfang | 4 |
| Fachzeitschrift | Bioorganic & medicinal chemistry letters : a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines |
| Jahrgang | 12 |
| Ausgabenummer | 3 |
| Publikationsstatus | Veröffentlicht - 11 Feb. 2002 |
| Peer-Review-Status | Ja |
Externe IDs
| Scopus | 0037060652 |
|---|
Schlagworte
Schlagwörter
- Acetylation, Anti-Bacterial Agents/biosynthesis, Chloramphenicol/analogs & derivatives, Chromatography, High Pressure Liquid, Hydrolysis, Magnetic Resonance Spectroscopy, Streptomyces/chemistry