Inferring country-specific import risk of diseases from the world air transportation network

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Pascal Peter Klamser - , Humboldt University of Berlin, Robert Koch-Institut (Author)
  • Simon Christian Adrian Zachariae - , Humboldt University of Berlin, Robert Koch-Institut (Author)
  • Benjamin F. Maier - , Robert Koch-Institut, Humboldt University of Berlin, Technical University of Denmark, University of Copenhagen (Author)
  • Olga Baranov - , Ludwig Maximilian University of Munich, German Center for Infection Research, Partner Site Munich (Author)
  • Clara Jongen - , Robert Koch-Institut, Humboldt University of Berlin (Author)
  • Frank Schlosser - , Robert Koch-Institut, Humboldt University of Berlin (Author)
  • Dirk Brockmann - , Chair of Biology of Complex Systems (SynoSys), Humboldt University of Berlin, Robert Koch-Institut (Author)

Abstract

Disease propagation between countries strongly depends on their effective distance, a measure derived from the world air transportation network (WAN). It reduces the complex spreading patterns of a pandemic to a wave-like propagation from the outbreak country, establishing a linear relationship to the arrival time of the unmitigated spread of a disease. However, in the early stages of an outbreak, what concerns decision-makers in countries is understanding the relative risk of active cases arriving in their country-essentially, the likelihood that an active case boarding an airplane at the outbreak location will reach them. While there are data-fitted models available to estimate these risks, accurate mechanistic, parameter-free models are still lacking. Therefore, we introduce the 'import risk' model in this study, which defines import probabilities using the effective-distance framework. The model assumes that airline passengers are distributed along the shortest path tree that starts at the outbreak's origin. In combination with a random walk, we account for all possible paths, thus inferring predominant connecting flights. Our model outperforms other mobility models, such as the radiation and gravity model with varying distance types, and it improves further if additional geographic information is included. The import risk model's precision increases for countries with stronger connections within the WAN, and it reveals a geographic distance dependence that implies a pull- rather than a push-dynamic in the distribution process.

Details

Original languageEnglish
Article number e1011775
Number of pages26
JournalPLoS Computational Biology
Volume20 (2024)
Issue number1
Publication statusPublished - 24 Jan 2024
Peer-reviewedYes

External IDs

Scopus 85183331444
PubMed 38266041

Keywords

Keywords

  • Disease Outbreaks, Aircraft, Pandemics

Library keywords