Inferring country-specific import risk of diseases from the world air transportation network

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Pascal Peter Klamser - , Humboldt-Universität zu Berlin, Robert Koch-Institut (Autor:in)
  • Simon Christian Adrian Zachariae - , Humboldt-Universität zu Berlin, Robert Koch-Institut (Autor:in)
  • Benjamin F. Maier - , Robert Koch-Institut, Humboldt-Universität zu Berlin, Technical University of Denmark, Universität Kopenhagen (Autor:in)
  • Olga Baranov - , Ludwig-Maximilians-Universität München (LMU), Deutsche Zentrum für Infektionsforschung, Standort München (Autor:in)
  • Clara Jongen - , Robert Koch-Institut, Humboldt-Universität zu Berlin (Autor:in)
  • Frank Schlosser - , Robert Koch-Institut, Humboldt-Universität zu Berlin (Autor:in)
  • Dirk Brockmann - , Professur für Biologie komplexer Systeme (SynoSys), Humboldt-Universität zu Berlin, Robert Koch-Institut (Autor:in)

Abstract

Disease propagation between countries strongly depends on their effective distance, a measure derived from the world air transportation network (WAN). It reduces the complex spreading patterns of a pandemic to a wave-like propagation from the outbreak country, establishing a linear relationship to the arrival time of the unmitigated spread of a disease. However, in the early stages of an outbreak, what concerns decision-makers in countries is understanding the relative risk of active cases arriving in their country-essentially, the likelihood that an active case boarding an airplane at the outbreak location will reach them. While there are data-fitted models available to estimate these risks, accurate mechanistic, parameter-free models are still lacking. Therefore, we introduce the 'import risk' model in this study, which defines import probabilities using the effective-distance framework. The model assumes that airline passengers are distributed along the shortest path tree that starts at the outbreak's origin. In combination with a random walk, we account for all possible paths, thus inferring predominant connecting flights. Our model outperforms other mobility models, such as the radiation and gravity model with varying distance types, and it improves further if additional geographic information is included. The import risk model's precision increases for countries with stronger connections within the WAN, and it reveals a geographic distance dependence that implies a pull- rather than a push-dynamic in the distribution process.

Titel in Übersetzung
Ableitung des länderspezifischen Importrisikos von Krankheiten aus dem weltweiten Luftverkehrsnetz

Details

OriginalspracheEnglisch
Aufsatznummer e1011775
FachzeitschriftPLoS Computational Biology
Jahrgang20
Ausgabenummer1
PublikationsstatusVeröffentlicht - 24 Jan. 2024
Peer-Review-StatusJa

Externe IDs

Scopus 85183331444
PubMed 38266041

Schlagworte

Schlagwörter

  • Disease Outbreaks, Aircraft, Pandemics