Individual behavioral trajectories shape whole-brain connectivity in mice
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
It is widely assumed that our actions shape our brains and that the resulting connections determine who we are. To test this idea in a reductionist setting, in which genes and environment are controlled, we investigated differences in neuroanatomy and structural covariance by ex vivo structural magnetic resonance imaging (MRI) in mice whose behavioral activity was continuously tracked for 3 months in a large, enriched environment. We confirmed that environmental enrichment increases mouse hippocampal volumes. Stratifying the enriched group according to individual longitudinal behavioral trajectories, however, revealed striking differences in mouse brain structural covariance in continuously highly active mice compared to those whose trajectories showed signs of habituat-ing activity. Network-based statistics identified distinct sub-networks of murine structural covariance underlying these differences in behavioral activity. Together, these results reveal that differentiated behavioral trajectories of mice in an enriched environment are associated with differences in brain connectivity.
Details
Original language | English |
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Article number | e80379 |
Number of pages | 18 |
Journal | eLife |
Volume | 12(2023) |
Publication status | Published - 16 Jan 2023 |
Peer-reviewed | Yes |
External IDs
Scopus | 85147139738 |
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WOS | 000940228500001 |
ORCID | /0000-0003-2132-4445/work/142236364 |
ORCID | /0000-0002-5304-4061/work/142238836 |
Keywords
Research priority areas of TU Dresden
DFG Classification of Subject Areas according to Review Boards
- Clinical Psychiatry, Psychotherapy and Child and Adolescent Psychiatry
- Massively Parallel and Data-Intensive Systems
- Experimental and Theoretical Network Neuroscience
- Experimental Models to Understand Diseases of the Nervous System
- Biological Psychiatry
- Differential, Clinical and Medical Psychology, Methods
ASJC Scopus subject areas
Keywords
- Adult neurogenesis, Behavioral tracking, Hippocampus, Individuality, Mouse, Structural covariance