In vitro microenvironments to study breast cancer bone colonisation

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

Abstract

Bone metastasis occurs frequently in patients with advanced breast cancer and is a major cause of morbidity and mortality in these patients. In order to advance current therapies, the mechanisms leading to the formation of bone metastases and their pathophysiology have to be better understood. Several in vitro models have been developed for systematic studies of interactions between breast cancer cells and the bone microenvironment. Such models can provide insights into the molecular basis of bone metastatic colonisation and also may provide a useful platform to design more physiologically relevant drug testing assays. This review describes different in vitro approaches and discusses their advantages and disadvantages.

Details

Original languageEnglish
Pages (from-to)135-144
Number of pages10
JournalAdvanced drug delivery reviews
Volume79
Publication statusPublished - 15 Dec 2014
Peer-reviewedYes

External IDs

PubMed 25453260

Keywords

Sustainable Development Goals

ASJC Scopus subject areas

Keywords

  • Bone metastasis, Breast cancer, In vitro model, Tissue engineering, Tumour microenvironment