In vitro microenvironments to study breast cancer bone colonisation

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

Abstract

Bone metastasis occurs frequently in patients with advanced breast cancer and is a major cause of morbidity and mortality in these patients. In order to advance current therapies, the mechanisms leading to the formation of bone metastases and their pathophysiology have to be better understood. Several in vitro models have been developed for systematic studies of interactions between breast cancer cells and the bone microenvironment. Such models can provide insights into the molecular basis of bone metastatic colonisation and also may provide a useful platform to design more physiologically relevant drug testing assays. This review describes different in vitro approaches and discusses their advantages and disadvantages.

Details

OriginalspracheEnglisch
Seiten (von - bis)135-144
Seitenumfang10
FachzeitschriftAdvanced drug delivery reviews
Jahrgang79
PublikationsstatusVeröffentlicht - 15 Dez. 2014
Peer-Review-StatusJa

Externe IDs

PubMed 25453260

Schlagworte

Ziele für nachhaltige Entwicklung

ASJC Scopus Sachgebiete

Schlagwörter

  • Bone metastasis, Breast cancer, In vitro model, Tissue engineering, Tumour microenvironment