HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
- Department of Radiotherapy and Radiooncology
- OncoRay - National Center for Radiation Research in Oncology
- Institute of Pathology
- University Cancer Centre Dresden
- SRH University of Applied Sciences Heidelberg
- German Cancer Consortium (DKTK) Partner Site Dresden
- University Hospital Carl Gustav Carus Dresden
- Charité – Universitätsmedizin Berlin
- University of Duisburg-Essen
- University Hospital Frankfurt
- Freiburg University of Education
- University Hospital Tübingen
- University of Texas at Austin
Abstract
OBJECTIVE: To investigate the impact of HPV status in patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received surgery and cisplatin-based postoperative radiochemotherapy.
MATERIALS AND METHODS: For 221 patients with locally advanced squamous cell carcinoma of the hypopharynx, oropharynx or oral cavity treated at the 8 partner sites of the German Cancer Consortium, the impact of HPV DNA, p16 overexpression and p53 expression on outcome were retrospectively analysed. The primary endpoint was loco-regional tumour control; secondary endpoints were distant metastases and overall survival.
RESULTS: In the total patient population, univariate analyses revealed a significant impact of HPV16 DNA positivity, p16 overexpression, p53 positivity and tumour site on loco-regional tumour control. Multivariate analysis stratified for tumour site showed that positive HPV 16 DNA status correlated with loco-regional tumour control in patients with oropharyngeal carcinoma (p=0.02) but not in the oral cavity carcinoma group. Multivariate evaluation of the secondary endpoints in the total population revealed a significant association of HPV16 DNA positivity with overall survival (p<0.01) but not with distant metastases.
CONCLUSIONS: HPV16 DNA status appears to be a strong prognosticator of loco-regional tumour control after postoperative cisplatin-based radiochemotherapy of locally advanced oropharyngeal carcinoma and is now being explored in a prospective validation trial.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 317-323 |
| Number of pages | 7 |
| Journal | Radiotherapy and Oncology |
| Volume | 113 |
| Issue number | 3 |
| Publication status | Published - Dec 2014 |
| Peer-reviewed | Yes |
External IDs
| Scopus | 84915817332 |
|---|---|
| researchoutputwizard | legacy.publication#61885 |
| PubMed | 25480095 |
| ORCID | /0000-0002-7017-3738/work/142253894 |
| ORCID | /0000-0003-1776-9556/work/171065646 |
Keywords
Sustainable Development Goals
Keywords
- Carcinoma, Squamous Cell/genetics, Chemoradiotherapy/methods, Cyclin-Dependent Kinase Inhibitor p16/genetics, DNA/genetics, Female, Head and Neck Neoplasms/genetics, Humans, Male, Oropharyngeal Neoplasms/genetics, Papillomaviridae/genetics, Postoperative Period, Prognosis, Prospective Studies, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck, Survival Analysis, Treatment Outcome