The combination of closed hollow profiles made of textile-thermoplastic composite materials with organo-sheets and their joint functionalization by injection molding presents an enormous potential for lightweight construction for highly stressed vehicle components. One major technical challenge here is the high process pressures in injection molding and the resulting stress on the hollow profiles. To prevent collapse of the hollow profiles during the filling and holding-pressure phase they must be stabilized from the inside by fluid supporting media or free-flowing particles. The present contribution presents an integrative process-structure simulation methodology for the prediction of profile deformations during injection-molding which are related to design and process.