Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.
Details
Original language | English |
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Pages (from-to) | 4997-5004 |
Number of pages | 8 |
Journal | Biomaterials science |
Volume | 8 |
Issue number | 18 |
Publication status | Published - 21 Sept 2020 |
Peer-reviewed | Yes |
External IDs
PubMed | 32931543 |
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ORCID | /0000-0003-0189-3448/work/161890290 |