Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 4997-5004 |
Seitenumfang | 8 |
Fachzeitschrift | Biomaterials science |
Jahrgang | 8 |
Ausgabenummer | 18 |
Publikationsstatus | Veröffentlicht - 21 Sept. 2020 |
Peer-Review-Status | Ja |
Externe IDs
PubMed | 32931543 |
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ORCID | /0000-0003-0189-3448/work/161890290 |