Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.

Details

OriginalspracheEnglisch
Seiten (von - bis)4997-5004
Seitenumfang8
FachzeitschriftBiomaterials science
Jahrgang8
Ausgabenummer18
PublikationsstatusVeröffentlicht - 21 Sept. 2020
Peer-Review-StatusJa

Externe IDs

PubMed 32931543
ORCID /0000-0003-0189-3448/work/161890290

Schlagworte