Helical motion and torque generation by microtubule motors

Research output: Contribution to journalReview articleContributedpeer-review

Abstract

Microtubule motors play key roles in cellular functions, such as transport, mitosis and cell motility. Fueled by ATP hydrolysis, they convert chemical energy into mechanical work, which enables their movement on microtubules. While their motion along the long axis of microtubules has been studied extensively, some motors display an off-axis component, which results in helical motion around microtubules and the generation of torque in addition to linear forces. Understanding these nuanced movements expands our comprehension of motor protein dynamics and their impact on cellular processes.

Details

Original languageEnglish
Article number102367
JournalCurrent opinion in cell biology
Volume88
Publication statusPublished - Jun 2024
Peer-reviewedYes

External IDs

PubMed 38735207
ORCID /0000-0002-0750-8515/work/161407029

Keywords

ASJC Scopus subject areas

Keywords

  • Microtubules/metabolism, Molecular Motor Proteins/metabolism, Torque, Humans, Animals