Grundlagen der Pharmakologie von Lokalanästhetika
Research output: Contribution to journal › Review article › Invited › peer-review
Contributors
Abstract
The development of local anesthetics revolutionized the performance of painful interventions. Local anesthetics have an effect on voltage-gated sodium channels in nerve fibers and modulate the conduction of impulses. With respect to the chemical structure, local anesthetics can be divided into amide and ester types. The structural differences of local anesthetics have an influence on the duration of action, the degradation pathways and specific side effects. Severe adverse events include cardiotoxicity and neurotoxicity. In addition to basic measures, such as the monitoring and securing of vital parameters, lipid infusion represents a treatment option in cases of intoxication. The recent developments of local anesthetics are particularly concerned with the reduction of toxicity and prolonging the duration of action.
Translated title of the contribution | Principles of the pharmacology of local anesthetics |
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Details
Original language | German |
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Pages (from-to) | 389-405 |
Number of pages | 17 |
Journal | Schmerz |
Volume | 37 |
Issue number | 5 |
Publication status | Published - Oct 2023 |
Peer-reviewed | Yes |
External IDs
Scopus | 85171439935 |
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ORCID | /0000-0001-8494-1403/work/145699009 |
Keywords
Research priority areas of TU Dresden
DFG Classification of Subject Areas according to Review Boards
Subject groups, research areas, subject areas according to Destatis
Sustainable Development Goals
Keywords
- Humans, Anesthetics, Local/toxicity, Amides, Esters, Pain