Future of clinical trials in the delivery room: time for pragmatism
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Despite increased amounts of research, most of the evidence that supports treatment of newborns in the delivery room is rated 'low' rather than 'high' quality. This assessment stems largely from a lack of evidence from clinical trials. When trials have been performed, the evidence has often been downgraded due to enrolment of small or poorly representative samples, and for lack of blinding of caregivers and outcome assessors. Delivery room trials present particular challenges when obtaining consent, enrolling participants, taking measures to limit bias and identifying appropriate outcome measures. We hope our suggestions as to how future delivery room trials could be more pragmatic will inform the design of large studies that are necessary to allow clinical practice to evolve.
Details
Original language | English |
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Pages (from-to) | 102-105 |
Number of pages | 4 |
Journal | Archives of disease in childhood : the journal of the Royal College of Paediatrics and Child Health |
Volume | 108 |
Issue number | 2 |
Publication status | Published - Mar 2023 |
Peer-reviewed | Yes |
External IDs
PubMed | 36162974 |
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Keywords
ASJC Scopus subject areas
Keywords
- Neonatology, Resuscitation, Pregnancy, Delivery Rooms, Humans, Female, Outcome Assessment, Health Care, Infant, Newborn