Future of clinical trials in the delivery room: time for pragmatism

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

Abstract

Despite increased amounts of research, most of the evidence that supports treatment of newborns in the delivery room is rated 'low' rather than 'high' quality. This assessment stems largely from a lack of evidence from clinical trials. When trials have been performed, the evidence has often been downgraded due to enrolment of small or poorly representative samples, and for lack of blinding of caregivers and outcome assessors. Delivery room trials present particular challenges when obtaining consent, enrolling participants, taking measures to limit bias and identifying appropriate outcome measures. We hope our suggestions as to how future delivery room trials could be more pragmatic will inform the design of large studies that are necessary to allow clinical practice to evolve.

Details

OriginalspracheEnglisch
Seiten (von - bis)102-105
Seitenumfang4
Fachzeitschrift Archives of disease in childhood : the journal of the Royal College of Paediatrics and Child Health. Fetal & neonatal
Jahrgang108
Ausgabenummer2
PublikationsstatusVeröffentlicht - März 2023
Peer-Review-StatusJa

Externe IDs

PubMed 36162974

Schlagworte

Schlagwörter

  • Neonatology, Resuscitation, Pregnancy, Delivery Rooms, Humans, Female, Outcome Assessment, Health Care, Infant, Newborn