Function and regulation of serine/threonine phosphatases in the healthy and diseased heart
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Protein phosphorylation is a major control mechanism of a wide range of physiological processes and plays an important role in cardiac pathophysiology. Serine/threonine protein phosphatases control the dephosphorylation of a variety of cardiac proteins, thereby fine-tuning cardiac electrophysiology and function. Specificity of protein phosphatases type-1 and type-2A is achieved by multiprotein complexes that target the catalytic subunits to specific subcellular domains. Here, we describe the composition, regulation and target substrates of serine/threonine phosphatases in the heart. In addition, we provide an overview of pharmacological tools and genetic models to study the role of cardiac phosphatases. Finally, we review the role of protein phosphatases in the diseased heart, particularly in ventricular arrhythmias and atrial fibrillation and discuss their role as potential therapeutic targets.
Details
Original language | English |
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Pages (from-to) | 90-98 |
Number of pages | 9 |
Journal | Journal of Molecular and Cellular Cardiology |
Volume | 64 |
Publication status | Published - Nov 2013 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 24051368 |
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ORCID | /0000-0003-2514-9429/work/150884077 |
Keywords
ASJC Scopus subject areas
Keywords
- Atrial fibrillation, Dephosphorylation, Heart failure, Protein phosphatases