Function and regulation of serine/threonine phosphatases in the healthy and diseased heart

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

  • Jordi Heijman - , Universität Duisburg-Essen (Autor:in)
  • Matthias Dewenter - , Georg-August-Universität Göttingen (Autor:in)
  • Ali El-Armouche - , Georg-August-Universität Göttingen, Universitätsmedizin Göttingen (Autor:in)
  • Dobromir Dobrev - , Universität Duisburg-Essen (Autor:in)

Abstract

Protein phosphorylation is a major control mechanism of a wide range of physiological processes and plays an important role in cardiac pathophysiology. Serine/threonine protein phosphatases control the dephosphorylation of a variety of cardiac proteins, thereby fine-tuning cardiac electrophysiology and function. Specificity of protein phosphatases type-1 and type-2A is achieved by multiprotein complexes that target the catalytic subunits to specific subcellular domains. Here, we describe the composition, regulation and target substrates of serine/threonine phosphatases in the heart. In addition, we provide an overview of pharmacological tools and genetic models to study the role of cardiac phosphatases. Finally, we review the role of protein phosphatases in the diseased heart, particularly in ventricular arrhythmias and atrial fibrillation and discuss their role as potential therapeutic targets.

Details

OriginalspracheEnglisch
Seiten (von - bis)90-98
Seitenumfang9
FachzeitschriftJournal of Molecular and Cellular Cardiology
Jahrgang64
PublikationsstatusVeröffentlicht - Nov. 2013
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 24051368
ORCID /0000-0003-2514-9429/work/150884077

Schlagworte

Schlagwörter

  • Atrial fibrillation, Dephosphorylation, Heart failure, Protein phosphatases