Fold-Hopf bursting in a model for calcium signal transduction

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • L Brusch - , Max-Planck-Institute for the Physics of Complex Systems (Author)
  • W Lorenz - (Author)
  • M Or-Guil - (Author)
  • M Bar - (Author)
  • U Kummer - (Author)

Abstract

We study a recent model for calcium Signal transduction. This model displays spiking, bursting and chaotic oscillations in accordance with experimental results. We calculate bifurcation diagrams and study the bursting behaviour in detail. This behaviour is classified according to the dynamics of separated slow and fast subsystems. It is shown to be of the Fold-Hopf type, a type which was previously only described in the context of neuronal systems, but not in the context of signal transduction in the cell.

Details

Original languageEnglish
Pages (from-to)487-497
Number of pages11
JournalZeitschrift fur Physikalische Chemie
Volume216
Issue number4
Publication statusPublished - 2002
Peer-reviewedYes
Externally publishedYes

External IDs

Scopus 85026128927
ORCID /0000-0003-0137-5106/work/142244238

Keywords

Keywords

  • bursting oscillations, signal transduction, calcium, GENE-EXPRESSION, OSCILLATIONS, BIFURCATIONS, MECHANISMS, FREQUENCY, SYSTEM, CHAOS