Photoreceptor cell transplantation into the mouse retina has been shown to result in the transfer of cytoplasmic material between donor and host photoreceptors. Recently it has been found that this inter-photoreceptor material transfer process is likely to be mediated by nanotube-like structures connecting donor and host photoreceptors. By leveraging cone-specific reporter mice and super-resolution microscopy we provide evidence for the transfer of cytoplasmic material also from endogenous cones to endogenous rod photoreceptors and the existence of nanotube-like cell-cell connections possibly mediating this process in the adult mouse retina, together with preliminary data indicating that horizontal material transfer may also occur in the human retina.
|Journal||Experimental Eye Research|
|Early online date||11 Mar 2022|
|Publication status||Published - 1 Jun 2022|
Research priority areas of TU Dresden
DFG Classification of Subject Areas according to Review Boards
Sustainable Development Goals
- Cell-cell connection, Cone, Material transfer, Photoreceptor, Rod, STORM, Animals, Retinal Cone Photoreceptor Cells, Retina, Mice, Mammals, Retinal Rod Photoreceptor Cells