Evidence for endogenous exchange of cytoplasmic material between a subset of cone and rod photoreceptors within the adult mammalian retina via direct cell-cell connections

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Photoreceptor cell transplantation into the mouse retina has been shown to result in the transfer of cytoplasmic material between donor and host photoreceptors. Recently it has been found that this inter-photoreceptor material transfer process is likely to be mediated by nanotube-like structures connecting donor and host photoreceptors. By leveraging cone-specific reporter mice and super-resolution microscopy we provide evidence for the transfer of cytoplasmic material also from endogenous cones to endogenous rod photoreceptors and the existence of nanotube-like cell-cell connections possibly mediating this process in the adult mouse retina, together with preliminary data indicating that horizontal material transfer may also occur in the human retina.

Details

Original languageEnglish
Article number109033
Pages (from-to)109033
JournalExperimental Eye Research
Volume219
Early online date11 Mar 2022
Publication statusPublished - 1 Jun 2022
Peer-reviewedYes

External IDs

Scopus 85126515824
Mendeley 338218b6-ad11-3bf3-80cf-b226fa9da0f2
unpaywall 10.1016/j.exer.2022.109033

Keywords

Research priority areas of TU Dresden

    DFG Classification of Subject Areas according to Review Boards

      Sustainable Development Goals

        Keywords

        • Cell-cell connection, Cone, Material transfer, Photoreceptor, Rod, STORM, Animals, Retinal Cone Photoreceptor Cells, Retina, Mice, Mammals, Retinal Rod Photoreceptor Cells