Ethanol-rundversuch zum verfahren-kombinierenden sollwert in einer qualitätskontrollprobe und zum bias zwischen GC- und ADH-verfahren

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Rolf Aderjan - , Heidelberg University  (Author)
  • Georg Schmitt - , Heidelberg University  (Author)
  • Andreas Alt - , Ulm University (Author)
  • Hilke Andresen - , University of Hamburg (Author)
  • Volker Auwärter - , University of Freiburg (Author)
  • Manfred Erkens - , RWTH Aachen University (Author)
  • Susanna Fehn - , Bayerisches Landeskriminalamt (Author)
  • Herbert Käferstein - , University of Cologne (Author)
  • Gerold Kauert - , University Hospital Frankfurt (Author)
  • Thomas Kaufmann - , Johannes Gutenberg University Mainz (Author)
  • Frank Musshoff - , University of Bonn (Author)
  • Jan Rohwer - , Kiel University (Author)
  • Katja Schulz - , Institute of Forensic Medicine (Author)
  • Jörg Teske - , Leibniz University Hannover (LUH) (Author)
  • Rolf Werner - , Friedrich Schiller University Jena (Author)

Abstract

14 German blood alcohol laboratories took part in an interlaboratory study for blood alcohol (ethanol) determination using a spiked quality control serum sample containing 1.36 g ethanol/L serum (1.10 g ethanol/kg whole blood). They examined the sample during 20 days in order to examine the scheduled value which was confirmed (1.11 g ethanol/kg whole blood). A total of 1120 individual ethanol determination were performed. As expected, the study proved that the average values found for the GC method and for the ADH method are not significantly different. The average bias between the GC and ADH measurements was -0.003 per mille (-0.3 %). According to the results of the study which was conducted in a concentration range above which in Germany driving under alcohol is sanctioned in terms of driving inability, we propose an absolute value of 5 % as a maximum allowable bias between the two alcohol determination procedures. This proposal relates to the control of precision and accuracy of each of the two methods and to in house setpoints of quality control samples which need to be determined during a 20 days period prior to their use as control sample in order to confirm scheduled values given by the provider.

Translated title of the contribution
Round robin test of the ethanol target concentration in a quality control sample and of the bias between two independent methods stipulated according to German guidelines

Details

Original languageGerman
Pages (from-to)237-243
Number of pages7
JournalBlutalkohol
Volume46
Issue number4
Publication statusPublished - Jul 2009
Peer-reviewedYes

Keywords

ASJC Scopus subject areas

Keywords

  • Accuracy, Blood alcohol determination, Control charts, Methods bias, Precision