Ethanol-rundversuch zum verfahren-kombinierenden sollwert in einer qualitätskontrollprobe und zum bias zwischen GC- und ADH-verfahren

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Rolf Aderjan - , Universität Heidelberg (Autor:in)
  • Georg Schmitt - , Universität Heidelberg (Autor:in)
  • Andreas Alt - , Universität Ulm (Autor:in)
  • Hilke Andresen - , Universität Hamburg (Autor:in)
  • Volker Auwärter - , Albert-Ludwigs-Universität Freiburg (Autor:in)
  • Manfred Erkens - , RWTH Aachen University (Autor:in)
  • Susanna Fehn - , Bayerisches Landeskriminalamt (Autor:in)
  • Herbert Käferstein - , Universität zu Köln (Autor:in)
  • Gerold Kauert - , Universitätsklinikum Frankfurt (Autor:in)
  • Thomas Kaufmann - , Johannes Gutenberg-Universität Mainz (Autor:in)
  • Frank Musshoff - , Universität Bonn (Autor:in)
  • Jan Rohwer - , Christian-Albrechts-Universität zu Kiel (CAU) (Autor:in)
  • Katja Schulz - , Institut für Rechtsmedizin (Autor:in)
  • Jörg Teske - , Leibniz Universität Hannover (LUH) (Autor:in)
  • Rolf Werner - , Friedrich-Schiller-Universität Jena (Autor:in)

Abstract

14 German blood alcohol laboratories took part in an interlaboratory study for blood alcohol (ethanol) determination using a spiked quality control serum sample containing 1.36 g ethanol/L serum (1.10 g ethanol/kg whole blood). They examined the sample during 20 days in order to examine the scheduled value which was confirmed (1.11 g ethanol/kg whole blood). A total of 1120 individual ethanol determination were performed. As expected, the study proved that the average values found for the GC method and for the ADH method are not significantly different. The average bias between the GC and ADH measurements was -0.003 per mille (-0.3 %). According to the results of the study which was conducted in a concentration range above which in Germany driving under alcohol is sanctioned in terms of driving inability, we propose an absolute value of 5 % as a maximum allowable bias between the two alcohol determination procedures. This proposal relates to the control of precision and accuracy of each of the two methods and to in house setpoints of quality control samples which need to be determined during a 20 days period prior to their use as control sample in order to confirm scheduled values given by the provider.

Details

OriginalspracheDeutsch
Seiten (von - bis)237-243
Seitenumfang7
FachzeitschriftBlutalkohol
Jahrgang46
Ausgabenummer4
PublikationsstatusVeröffentlicht - Juli 2009
Peer-Review-StatusJa

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • Accuracy, Blood alcohol determination, Control charts, Methods bias, Precision