Emergence and clonal expansion of Klebsiella pneumoniae ST307, simultaneously producing KPC-3 and NDM-1

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Daniela Cejas - , National Scientific and Technical Research Council Argentina (CONICET) (Author)
  • Francisco Magariños - , Ciudad Autónoma de Buenos Aires (Author)
  • Alan Elena - , National Scientific and Technical Research Council Argentina (CONICET), Universidad de Buenos Aires (Author)
  • Micaela Ferrara - , National Scientific and Technical Research Council Argentina (CONICET) (Author)
  • Cecilia Ormazábal - , Ciudad Autónoma de Buenos Aires (Author)
  • María Valeria Yernazian - , Ciudad Autónoma de Buenos Aires (Author)
  • Gabriel Gutkind - , National Scientific and Technical Research Council Argentina (CONICET) (Author)
  • Marcela Radice - , National Scientific and Technical Research Council Argentina (CONICET) (Author)

Abstract

MDR Klebsiella pneumoniae ST307 is a high-risk clone, whose genetic features contribute to its adaptation to hospital environments and the human host. This study describes the emergence and clonal dissemination of K. pneumoniae ST307, recovered during November 2018 to February 2019 in a hospital in Buenos Aires city, which concurrently harbored KPC-3 and NDM-1. These isolates were resistant to all β-lactams and to the ceftazidime/avibactam combination. Molecular studies showed that blaKPC-3 was located in Tn4401a platform, while blaNDM-1 was surrounded upstream by ISKpn14 followed by a partial sequence of ISAba125 and downstream by bleMBL-trpF, located in a 145.5 kb conjugative plasmid belonging to the Inc A/C group. The dissemination of K. pneumoniae ST307 isolates co-producing KPC-3 and NDM-1 could lead to a worrisome scenario due to the remarkable features of this clone and its resistance profile.

Details

Original languageEnglish
Pages (from-to)288-292
Number of pages5
JournalRevista Argentina de Microbiologia
Volume54
Issue number4
Publication statusPublished - 1 Oct 2022
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 35753832
ORCID /0000-0001-5372-0923/work/142242991

Keywords

ASJC Scopus subject areas

Keywords

  • Argentina, IncA/C, Klebsiella pneumoniae, KPC-3, NDM-1, ST307 high-risk clone

Library keywords