Emergence and clonal expansion of Klebsiella pneumoniae ST307, simultaneously producing KPC-3 and NDM-1

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Daniela Cejas - , Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (Autor:in)
  • Francisco Magariños - , Ciudad Autónoma de Buenos Aires (Autor:in)
  • Alan Elena - , Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires (Autor:in)
  • Micaela Ferrara - , Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (Autor:in)
  • Cecilia Ormazábal - , Ciudad Autónoma de Buenos Aires (Autor:in)
  • María Valeria Yernazian - , Ciudad Autónoma de Buenos Aires (Autor:in)
  • Gabriel Gutkind - , Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (Autor:in)
  • Marcela Radice - , Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (Autor:in)

Abstract

MDR Klebsiella pneumoniae ST307 is a high-risk clone, whose genetic features contribute to its adaptation to hospital environments and the human host. This study describes the emergence and clonal dissemination of K. pneumoniae ST307, recovered during November 2018 to February 2019 in a hospital in Buenos Aires city, which concurrently harbored KPC-3 and NDM-1. These isolates were resistant to all β-lactams and to the ceftazidime/avibactam combination. Molecular studies showed that blaKPC-3 was located in Tn4401a platform, while blaNDM-1 was surrounded upstream by ISKpn14 followed by a partial sequence of ISAba125 and downstream by bleMBL-trpF, located in a 145.5 kb conjugative plasmid belonging to the Inc A/C group. The dissemination of K. pneumoniae ST307 isolates co-producing KPC-3 and NDM-1 could lead to a worrisome scenario due to the remarkable features of this clone and its resistance profile.

Details

OriginalspracheEnglisch
Seiten (von - bis)288-292
Seitenumfang5
FachzeitschriftRevista Argentina de Microbiologia
Jahrgang54
Ausgabenummer4
PublikationsstatusVeröffentlicht - 1 Okt. 2022
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 35753832
ORCID /0000-0001-5372-0923/work/142242991

Schlagworte

Schlagwörter

  • Argentina, IncA/C, Klebsiella pneumoniae, KPC-3, NDM-1, ST307 high-risk clone

Bibliotheksschlagworte