No isolated system may ever support complexity. Emergent phenomena may however appear in an open system, if, as established by the Edge of Chaos theory, some of its constitutive elements feature the capability to amplify infinitesimal fluctuations in energy, provided an external source supplies them with a sufficient amount of DC power, which is known to be a signature for locally-active behaviour. In particular, complex behaviours, including static and dynamic pattern formation, may emerge in arrays of identical diffusively-coupled cells, if and only if the basic unit is poised on a particular sub-domain of the Local Activity regime, referred to as Edge of Chaos, within which a quiet state hides in fact a high degree of excitability. Here we show, for the first time, that these counterintuitive phenomena may emerge in a basic memristor cellular neural network, consisting of two identical diffusively-coupled second-order cells. The proposed bio-inspired array represents the simplest ever-reported open system, which reproduces the shocking phenomenon, reported by Smale in 1974, when, while studying a model from cellular biology, he observed two identical reaction cells, “mathematically dead” on their own, pulsating together upon diffusive coupling. Impressively, the bio-inspired two-cell reaction-diffusion network contains only nine circuit elements, specifically two DC voltage sources, three linear resistors, two linear capacitors, and two functional niobium oxide (NbO) memristors from NaMLab. Applying the theory of Local Activity to an accurate model of the memristor oscillator, a comprehensive picture for its local and global dynamics may be drawn, providing a systematic method to tune the design parameters of the two-cell array to enable diffusion-driven instabilities therein.