Don't trick me twice!

Research output: Contribution to journalEditorial (Lead article)Invitedpeer-review

Contributors

Abstract

Chemotherapy-induced nephrotoxicity limits the success of cancer therapy. Landau et al. now describe a mechanism by which a first dose of cisplatin renders the kidney sensitive to necroptosis mediated by a second dose. Unresolved injury and sustained necrosis, therefore, may represent a pathophysiological means of transition from acute kidney injury to chronic kidney disease.

Details

Original languageEnglish
Pages (from-to)736-738
Number of pages3
JournalKidney international
Volume95
Issue number4
Publication statusPublished - Apr 2019
Peer-reviewedYes

External IDs

Scopus 85062805616
ORCID /0000-0001-6287-9725/work/145698891
ORCID /0000-0002-9728-1413/work/145699157

Keywords

Sustainable Development Goals

Keywords

  • Acute Kidney Injury, Cisplatin, Humans, Kidney, Necrosis, Renal Insufficiency, Chronic