DNA Pre-Alignment Filter Using Processing Near Racetrack Memory

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Recent DNA pre-alignment filter designs employ DRAM for storing the reference genome and its associated meta-data. However, DRAM incurs increasingly high energy consumption of background and refresh energy as devices scale. To overcome this problem, this paper explores a design with racetrack memory (RTM)-an emerging non-volatile memory that promises higher storage density, faster access latency, and lower energy consumption. Multi-bit storage cells in RTM are inherently sequential and thus require data placement strategies to mitigate the performance and energy impacts of shifting during data accesses. We propose a near-memory pre-alignment filter with a novel data mapping and several shift reduction strategies designed explicitly for RTM. On a set of four input genomes from the 1000 Genome Project, our approach improves performance and energy efficiency by 68% and 52%, respectively, compared to the state-of-the-art DRAM-based architecture.

Details

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalIEEE computer architecture letters
Volume21 (2022)
Issue number2
Publication statusPublished - 22 Jul 2022
Peer-reviewedYes

External IDs

ORCID /0000-0002-5007-445X/work/160049130

Keywords

Sustainable Development Goals

ASJC Scopus subject areas

Keywords

  • DNA sequence alignment, genome sequencing, processing-in-memory, seed location filtering

Library keywords