Differences in the regenerative response of neuronal cell populations and indications for plasticity in intraspinal neurons after spinal cord transection in adult zebrafish

Research output: Contribution to journalResearch articleContributedpeer-review


  • Thomas Becker - , University of Hamburg (Author)
  • Bettina C. Lieberoth - , University of Hamburg (Author)
  • Catherina G. Becker - , University of Hamburg (Author)
  • Melitta Schachner - , University of Hamburg (Author)


In zebrafish, the capacity to regenerate long axons varies among different populations of axotomized neurons after spinal cord transection. In specific brain nuclei, 84-92% of axotomized neurons upregulate expression of the growth-related genes GAP-43 and L1.1 and 32-51% of these neurons regrow their descending axons. In contrast, 16-31% of spinal neurons with axons ascending to the brainstem upregulate these genes and only 2-4% regrow their axons. Dorsal root ganglion (DRG) neurons were not observed to regrow their ascending axons or to increase expression of GAP-43 mRNA. Expression of L1.1 mRNA is high in unlesioned and axotomized DRG neurons. In the lesioned spinal cord, expression of growth-related molecules is increased in a substantial population of non-axotomized neurons, suggesting morphological plasticity in the spinal-intrinsic circuitry. We propose that locomotor recovery in spinal-transected adult zebrafish is influenced less by recovery of ascending pathways, but more by regrowth of descending tracts and rearrangement of intraspinal circuitry.


Original languageEnglish
Pages (from-to)265-278
Number of pages14
JournalMolecular and Cellular Neuroscience
Issue number2
Publication statusPublished - Oct 2005
Externally publishedYes

External IDs

PubMed 16098761