Der Einfluss von Industrie-Sponsoring auf Forschungsergebnisse randomisierter klinischer Studien in der Plastischen und n Chirurgie: Eine Querschnittsanalyse der letzten 12 Jahre

Research output: Contribution to journalResearch articleContributedpeer-review

Abstract

Background Industry funding of research studies can cause the results in the field of plastic, reconstructive and aesthetic surgery to be biased towards the sponsors. This paper aims to review randomised clinical trials (RCTs) published by leading international journals in plastic, reconstructive and aesthetic surgery with respect to characteristics and possible industry-friendly conclusions in favour of those funding the study. Material and Methods Characteristic data and funding of RCTs published by leading international plastic surgery journals from January 2010 to January 2022 were evaluated. The studies were categorised based on their thematic focus and the results in light of the existing funding. Results A total of 381 RCTs were included in the analysis, 68.5% of which were from a university (n=261). The larger proportion of studies did not disclose any information about the research funding. While 26% (n=98) of the studies analysed were funded by companies, 9.7% (n=37) were funded by universities/the government (p<0.05, 95% confidence interval). The overall focus of private clinics was aesthetics (n=32). Generally, the topic aesthetics (n=153) was funded by industry in 28 of 100 cases (28% industry/private sponsors compared with 9% university/government). Regarding reconstruction/burns/hand surgery, 9.2% of studies were funded by companies/private sponsors. Funding for research by university-based institutions was industry-sponsored in 25% (n=64) of cases. Regarding industry-sponsored studies, 73% (n=71) of the results were product-friendly in their conclusion (p<0.05, 95% confidence interval) and placed their thematic focus on therapeutic drug/product application (n=50, 75%). Conclusion In terms of funding, industry and private sponsors take a leading role both in reconstruction and aesthetics. Nonetheless, the majority of the evaluated studies were not financed by the private sector. In cases where the research was funded by private companies, the results were significantly in favour of the product. Aesthetics as a focus is currently more frequently funded by industry than reconstruction, burn, and hand surgery.

Translated title of the contribution
The Impact of Industrial Sponsorship on Research Findings in Randomised Clinical Trials in Plastic and Aesthetic Surgery
A Cross- Section Analysis of the Past 12 Years

Details

Original languageGerman
Pages (from-to)132-139
Number of pages8
Journal Handchirurgie, Mikrochirurgie, plastische Chirurgie : HaMiPla
Volume55
Issue number2
Early online date9 Feb 2023
Publication statusPublished - Apr 2023
Peer-reviewedYes

External IDs

PubMed 36758580
ORCID /0000-0003-4633-2695/work/145698719
WOS 000935067200002
Mendeley b47d0bcd-d3ab-39e8-bb15-1a2fd3bc1237

Keywords

Research priority areas of TU Dresden

DFG Classification of Subject Areas according to Review Boards

Subject groups, research areas, subject areas according to Destatis

Keywords

  • conflict of interest, plastic surgery, randomised clinical trial, Conflict of interest, Plastic surgery, Randomised clinical trial

Library keywords