Deep learning for interpretable end-to-end survival (E-E Surv) prediction in gastrointestinal cancer histopathology
Research output: Contribution to journal › Conference article › Contributed › peer-review
Contributors
Abstract
Digitized histopathology slides contain a wealth of information, only a fraction of which is being used in clinical routine. Deep learning can extract subtle visual features from digitized slides and thus can infer clinically relevant endpoints from raw image data. While classification and regression methods are well established in this domain, end-to-end prediction of patient survival still remains a comparably novel approach. To account for different follow-up times and censored data, previous approaches have largely used discretized survival data. Here, we demonstrate and validate EE-Surv, a powerful yet algorithmically simple method to predict survival directly from whole slide images which we validate in colorectal and gastric cancer, two clinically relevant and markedly different tumor types. We experimentally show that this method yields a highly significant prediction of survival and enables explainability of predictions. This method is publicly available under an open-source license and can be applied to any type of disease.
Details
Original language | English |
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Pages (from-to) | 81-93 |
Number of pages | 13 |
Journal | Proceedings of Machine Learning Research |
Volume | 156 |
Publication status | Published - 2021 |
Peer-reviewed | Yes |
Externally published | Yes |
Conference
Title | 2021 MICCAI Workshop on Computational Pathology, COMPAY 2021 |
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Duration | 27 September 2021 |
City | Virtual, Online |
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- Convolutional Neural Network, Deep Learning, Digitized Histopathology Images, Survival Prediction, Transfer Learning