Crique: A System for Automatic Extraction and Formalization of Eligibility Criteria for Clinical Trials

Research output: Contribution to book/Conference proceedings/Anthology/Report › Conference contribution › Contributed › peer-review

Abstract

Defining formal and structured eligibility criteria for digital recruitment assistant systems can be a challenging interdisciplinary task requiring collaboration between technical and clinical experts. We introduce crique, a free and open source software capable of extracting formal eligibility criteria definitions from study protocols. The extracted eligibility criteria can be exported to OHDSI Atlas and used in conjunction with the standardized OMOP common data model. In this paper, we present our modular process for the extraction of eligibility criteria, describe our implementation in detail, and show examples of extracted eligibility criteria. We conclude with challenges and propose a strategy to evaluate the accuracy of extracted criteria using our software.

Details

Original languageEnglish
Title of host publicationOpening the Personal Gate between Technology and Health Care
EditorsMaria Hagglund, Lars Lindskold, Lenka Lhotska, Sara Marceglia, Enea Parimbelli, Lucia Sacchi, Paolo Soda, Lacramioara Stoicu-Tivadar, Pierangelo Veltri, Patrizia Vizza, Mauro Giacomini, Jaime Delgado, Theodoros N. Arvanitis, Elisavet Andrikopoulou, Arriel Benis, Gabriella Balestra, Riccardo Bellazzi, Parisis G. Gallos, Roberto Gatta, Daniele Roberto Giacobbe, Noemi Giordano
Pages804-808
Number of pages5
ISBN (electronic)978-1-64368-661-5
Publication statusPublished - 21 May 2026
Peer-reviewedYes

Publication series

SeriesStudies in health technology and informatics
Volume336
ISSN0926-9630

External IDs

Scopus 105039957482
ORCID /0000-0002-5002-2676/work/228961604
ORCID /0000-0002-7609-1565/work/228962069

Keywords

Keywords

  • Clinical Trials as Topic/methods, Eligibility Determination/methods, Humans, Patient Selection, Software