Comprehensive proteomic profiling of serum extracellular vesicles in patients with colorectal liver metastases identifies a signature for non-invasive risk stratification and early-response evaluation

Kuailu Lin; Franziska Baenke; Xixi Lai; Martin Schneider; Dominic Helm; Heike Polster; Venkatesh S Rao; Nicole Ganig; Fang Cheng Wong; Lena Seifert; Adrian M Seifert; Beatrix Jahnke; Nicole Kretschmann; Tjalf Ziemssen; Fee Klupp; Thomas Schmidt; Martin Schneider; Yi Han; Tim F Weber; Verena Plodeck; Heiner Nebelung; Nathalie Schmitt; Felix Korell; Bruno C Köhler; Carina Riediger; Jürgen Weitz; Nuh N Rahbari; Christoph Kahlert

doi:10.1186/s12943-022-01562-4

Comprehensive proteomic profiling of serum extracellular vesicles in patients with colorectal liver metastases identifies a signature for non-invasive risk stratification and early-response evaluation

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

Kuailu Lin - , Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Dresden, The First Affiliated Hospital of Chongqing Medical University, Mayo Clinic College of Medicine and Science, Zhejiang University (Author)
Franziska Baenke - , Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Dresden, German Cancer Research Center (DKFZ) (Author)
Xixi Lai - , Department of Visceral, Thoracic and Vascular Surgery, Institute for Immunology, University Hospital Carl Gustav Carus Dresden, Charité – Universitätsmedizin Berlin, Mayo Clinic College of Medicine and Science, Sir Run Run Shaw Hospital, Zhejiang University (Author)
Martin Schneider - , Department of internal Medicine I, MS-Based Protein Analysis Unit, German Cancer Research Center (DKFZ), Heidelberg University (Author)
Dominic Helm - , MS-Based Protein Analysis Unit (Author)
Heike Polster - , Department of Visceral, Thoracic and Vascular Surgery, Department of internal Medicine with focus on Cardiology (at Herzzentrum Dresden), University Medicine (Faculty of Medicine and University Hospital), University Hospital Carl Gustav Carus Dresden (Author)
Venkatesh S Rao - , Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Dresden (Author)
Nicole Ganig - , Department of Visceral, Thoracic and Vascular Surgery, Chair of Molecular Biotechnology, University Hospital Carl Gustav Carus Dresden, German Cancer Research Center (DKFZ) (Author)
Fang Cheng Wong - , Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Dresden (Author)
Lena Seifert - , Department of Visceral, Thoracic and Vascular Surgery, National Center for Tumor Diseases (Partners: UKD, MFD, HZDR, DKFZ), University Hospital Carl Gustav Carus Dresden, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT) Dresden (Author)
Adrian M Seifert - , Department of Visceral, Thoracic and Vascular Surgery, National Center for Tumor Diseases (Partners: UKD, MFD, HZDR, DKFZ), University Hospital Carl Gustav Carus Dresden, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT) Dresden (Author)
Beatrix Jahnke - , University Hospital Carl Gustav Carus Dresden (Author)
Nicole Kretschmann - , University Hospital Carl Gustav Carus Dresden (Author)
Tjalf Ziemssen - , Department of Neurology, Center of Clinical Neuroscience, Centre of Clinical Neuroscience, University Hospital Carl Gustav Carus Dresden (Author)
Fee Klupp - , University Hospital Heidelberg (Author)
Thomas Schmidt - , Chair of Plant Cell and Molecular Biology, Department of Visceral, Thoracic and Vascular Surgery, Department of internal Medicine 3, University Hospital Heidelberg, Uniklinik Köln (Author)
Martin Schneider - , Department of internal Medicine I, University Hospital Heidelberg (Author)
Yi Han - , Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Dresden (Author)
Tim F Weber - , University Hospital Heidelberg (Author)
Verena Plodeck - , Institute and Polyclinic of Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus Dresden (Author)
Heiner Nebelung - , Institute and Polyclinic of Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus Dresden (Author)
Nathalie Schmitt - , University Hospital Heidelberg (Author)
Felix Korell - , University Hospital Heidelberg (Author)
Bruno C Köhler - , University Hospital Heidelberg (Author)
Carina Riediger - , Department of Visceral, Thoracic and Vascular Surgery, National Center for Tumor Diseases (Partners: UKD, MFD, HZDR, DKFZ), University Hospital Carl Gustav Carus Dresden (Author)
Jürgen Weitz - , University Hospital Carl Gustav Carus Dresden (Author)
Nuh N Rahbari - , Heidelberg University (Author)
Christoph Kahlert - , Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Dresden, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT) Dresden (Author)

Details

Original language	English
Pages (from-to)	91
Journal	Molecular cancer
Volume	21
Issue number	1
Publication status	Published - 1 Apr 2022
Peer-reviewed	Yes

External IDs

PubMedCentral	PMC8973547
Scopus	85127439153
ORCID	/0000-0002-5329-3164/work/147141072
ORCID	/0000-0001-5061-9643/work/147674436
ORCID	/0000-0001-9389-4688/work/150330133

Keywords

Colorectal Neoplasms/genetics, Extracellular Vesicles, Humans, Liver Neoplasms/secondary, Proteomics, Risk Assessment

Research Portal of the TU Dresden

Contributors

Details

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Keywords

Keywords