Collective dynamics of interacting molecular motors

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • O. Campàs - , French National Centre for Scientific Research (CNRS), University of Barcelona (Author)
  • Y. Kafri - , French National Centre for Scientific Research (CNRS), Technion-Israel Institute of Technology (Author)
  • K. B. Zeldovich - , Harvard University (Author)
  • J. Casademunt - , University of Barcelona (Author)
  • J. F. Joanny - , French National Centre for Scientific Research (CNRS), Institut Curie (Author)

Abstract

The collective dynamics of N interacting processive molecular motors are considered theoretically when an external force is applied to the leading motor. We show, using a discrete lattice model, that the force-velocity curves strongly depend on the effective dynamic interactions between motors and differ significantly from those of a simple approach where the motors equally share the force. Moreover, they become essentially independent of the number of motors if N is large enough (N□5 for conventional kinesin). We show that a two-state ratchet model has a very similar behavior to that of the coarse-grained lattice model with effective interactions. The general picture is unaffected by motor attachment and detachment events.

Details

Original languageEnglish
Article number038101
JournalPhysical review letters
Volume97
Issue number3
Publication statusPublished - 2006
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 16907545

Keywords

ASJC Scopus subject areas