Collective dynamics of interacting molecular motors

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • O. Campàs - , Centre national de la recherche scientifique (CNRS), University of Barcelona (Autor:in)
  • Y. Kafri - , Centre national de la recherche scientifique (CNRS), Technion-Israel Institute of Technology (Autor:in)
  • K. B. Zeldovich - , Harvard University (Autor:in)
  • J. Casademunt - , University of Barcelona (Autor:in)
  • J. F. Joanny - , Centre national de la recherche scientifique (CNRS), Institut Curie (Autor:in)

Abstract

The collective dynamics of N interacting processive molecular motors are considered theoretically when an external force is applied to the leading motor. We show, using a discrete lattice model, that the force-velocity curves strongly depend on the effective dynamic interactions between motors and differ significantly from those of a simple approach where the motors equally share the force. Moreover, they become essentially independent of the number of motors if N is large enough (N□5 for conventional kinesin). We show that a two-state ratchet model has a very similar behavior to that of the coarse-grained lattice model with effective interactions. The general picture is unaffected by motor attachment and detachment events.

Details

OriginalspracheEnglisch
Aufsatznummer038101
FachzeitschriftPhysical review letters
Jahrgang97
Ausgabenummer3
PublikationsstatusVeröffentlicht - 2006
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 16907545

Schlagworte

ASJC Scopus Sachgebiete