Collective dynamics of interacting molecular motors
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
The collective dynamics of N interacting processive molecular motors are considered theoretically when an external force is applied to the leading motor. We show, using a discrete lattice model, that the force-velocity curves strongly depend on the effective dynamic interactions between motors and differ significantly from those of a simple approach where the motors equally share the force. Moreover, they become essentially independent of the number of motors if N is large enough (N□5 for conventional kinesin). We show that a two-state ratchet model has a very similar behavior to that of the coarse-grained lattice model with effective interactions. The general picture is unaffected by motor attachment and detachment events.
Details
Originalsprache | Englisch |
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Aufsatznummer | 038101 |
Fachzeitschrift | Physical review letters |
Jahrgang | 97 |
Ausgabenummer | 3 |
Publikationsstatus | Veröffentlicht - 2006 |
Peer-Review-Status | Ja |
Extern publiziert | Ja |
Externe IDs
PubMed | 16907545 |
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