Chronische oder schwere Darmerkrankung und Immundefekt: Manchmal ist es doch ein Kolibri
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
In the work-up of chronic enteropathies an underlying inborn error of immunity (IEI) should be considered in certain cases. IEI are rare, but approximately 10% of patients may present with symptoms of inflammatory bowel disease (IBD), which is a much more common entity. Patients with IEI associated IBD may show extraintestinal symptoms or signs, and are often refractory to conventional anti-inflammatory treatment. In case of early-onset bowel inflammation and other intestinal or extraintestinal manifestations, an IEI should be excluded. A small fraction of monogenic IEI can be amenable to targeted therapies, or even corrected by allogeneic stem cell transplantation. Therefore, early diagnosis is crucial. This paper shows examples of clinical - gastrointestinal as well as extraintestinal - signs and findings which require immunological and possibly genetic workup.
Translated title of the contribution | Chronic or severe enteropathy and immunodeficiency be prepared for a rara avis |
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Details
Original language | German |
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Pages (from-to) | 1668-1677 |
Number of pages | 10 |
Journal | Zeitschrift fur Gastroenterologie |
Volume | 60 |
Issue number | 11 |
Publication status | Published - 16 Mar 2022 |
Peer-reviewed | Yes |
External IDs
Scopus | 85127650633 |
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unpaywall | 10.1055/a-1709-5024 |
Mendeley | 6dee895d-a1cf-32ea-9f96-1775053b687b |
ORCID | /0009-0003-6519-0482/work/143074877 |
Keywords
Research priority areas of TU Dresden
DFG Classification of Subject Areas according to Review Boards
ASJC Scopus subject areas
Keywords
- Humans, Inflammatory Bowel Diseases/diagnosis, Inflammation