Chronische oder schwere Darmerkrankung und Immundefekt: Manchmal ist es doch ein Kolibri
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
In the work-up of chronic enteropathies an underlying inborn error of immunity (IEI) should be considered in certain cases. IEI are rare, but approximately 10% of patients may present with symptoms of inflammatory bowel disease (IBD), which is a much more common entity. Patients with IEI associated IBD may show extraintestinal symptoms or signs, and are often refractory to conventional anti-inflammatory treatment. In case of early-onset bowel inflammation and other intestinal or extraintestinal manifestations, an IEI should be excluded. A small fraction of monogenic IEI can be amenable to targeted therapies, or even corrected by allogeneic stem cell transplantation. Therefore, early diagnosis is crucial. This paper shows examples of clinical - gastrointestinal as well as extraintestinal - signs and findings which require immunological and possibly genetic workup.
Details
Originalsprache | Deutsch |
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Seiten (von - bis) | 1668-1677 |
Seitenumfang | 10 |
Fachzeitschrift | Zeitschrift fur Gastroenterologie |
Jahrgang | 60 |
Ausgabenummer | 11 |
Publikationsstatus | Veröffentlicht - 16 März 2022 |
Peer-Review-Status | Ja |
Externe IDs
Scopus | 85127650633 |
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unpaywall | 10.1055/a-1709-5024 |
Mendeley | 6dee895d-a1cf-32ea-9f96-1775053b687b |
ORCID | /0009-0003-6519-0482/work/143074877 |
Schlagworte
Forschungsprofillinien der TU Dresden
DFG-Fachsystematik nach Fachkollegium
ASJC Scopus Sachgebiete
Schlagwörter
- Humans, Inflammatory Bowel Diseases/diagnosis, Inflammation