Chemical constituents of the soft corals Sinularia vanderlandi and Sinularia gravis from the coast of Madagascar

Research output: Contribution to journalResearch articleContributedpeer-review



The crude extracts of the Madagascan soft corals Sinularia vanderlandi and Sinularia gravis (Alcyoniidae) showed activity against Plasmodium falciparum which led us to study their chemical constituents. The new cadinane-type sesquiterpenoid vanderlandin (1) has been obtained from S. vanderlandi along with 24-methylenecholesterol (2). Four new compounds, the spatane-type diterpenoid gravilin (3), the monoalkylmonoacylglycerol 4, the dihomoditerpenoid ketone 5, and isodecaryiol (9), along with the three known compounds (+)-(S)-geranyllinalool (6), (-)-(R)-nephthenol (7), and 11,12-epoxysarcophytol A (8) have been isolated from the methanol extract of S. gravis. The structures were elucidated based on extensive spectroscopic methods, in particular various 2D NMR techniques. The structure of isodecaryiol (9) including its absolute configuration could be confirmed by X-ray diffraction.


Original languageEnglish
Pages (from-to)989-1001
Number of pages13
JournalOrganic and Biomolecular Chemistry
Issue number3
Publication statusPublished - 21 Jan 2016

External IDs

PubMed 26626232
Scopus 84983208365
WOS 000368687600024
ORCID /0000-0003-3383-9518/work/142248548



  • Animals, Anthozoa/chemistry, Antiprotozoal Agents/analysis, Madagascar, Models, Molecular, Sesquiterpenes/analysis