CD-CODE: crowdsourcing condensate database and encyclopedia

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Nadia Rostam - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Soumyadeep Ghosh - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Chi Fung Willis Chow - , Clusters of Excellence PoL: Physics of Life, Faculty of Biology, Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD), TUD Dresden University of Technology (Author)
  • Anna Hadarovich - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Cedric Landerer - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Rajat Ghosh - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD) (Author)
  • Hong Kee Moon - , Max Planck Institute of Molecular Cell Biology and Genetics (Author)
  • Lena Hersemann - , Max Planck Institute of Molecular Cell Biology and Genetics (Author)
  • Diana M. Mitrea - , Dewpoint Therapeutics (Author)
  • Isaac A. Klein - , Dewpoint Therapeutics (Author)
  • Anthony A. Hyman - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD), TUD Dresden University of Technology (Author)
  • Agnes Toth-Petroczy - , Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden (CSBD), TUD Dresden University of Technology, Clusters of Excellence PoL: Physics of Life (Author)

Abstract

The discovery of biomolecular condensates transformed our understanding of intracellular compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about the function and composition of biomolecular condensates, we developed the crowdsourcing condensate database and encyclopedia (cd-code.org). CD-CODE is a community-editable platform, which includes a database of biomolecular condensates based on the literature, an encyclopedia of relevant scientific terms and a crowdsourcing web application. Our platform will accelerate the discovery and validation of biomolecular condensates, and facilitate efforts to understand their role in disease and as therapeutic targets.

Details

Original languageEnglish
Pages (from-to)673-676
Number of pages4
JournalNature methods
Volume20
Issue number5
Publication statusPublished - May 2023
Peer-reviewedYes

External IDs

PubMed 37024650