Buckling Instability of Viral Capsids—A Continuum Approach

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

The crystallographic structure of spherical viruses is modeled using a multiscale approach combining a macroscopic Helfrich model for morphology evolution with a microscopic approximation of a classical density functional theory for the protein interactions. The derivation of the model is based on energy dissipation and conservation of protein number density. The resulting set of equations is solved within a diffuse domain approach using finite elements and shows buckling transitions of spherical shapes into faceted viral shapes.

Details

Original languageEnglish
Pages (from-to)82-110
JournalMultiscale modeling & simulation
Volume10
Issue number1
Publication statusPublished - 2012
Peer-reviewedYes

External IDs

WOS 000302183800005
Scopus 84861492057

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Library keywords