Automated Generation of Conditional Moment Equations for Stochastic Reaction Networks
Research output: Contribution to book/Conference proceedings/Anthology/Report › Conference contribution › Contributed › peer-review
Contributors
Abstract
The dynamics of biochemical reaction networks require a stochastic description when copy number fluctuations become significant. Such description is provided by moment equations that capture the statistical properties of the involved molecular components such as their average abundance and variability. Certain applications require a special form of moment equations, where the statistics of some components are described conditionally on complete trajectories of other components. Typical examples include information theoretical analyses of biochemical networks, model reduction and subnetwork simulation, or statistical inference where time-varying molecular signals are inferred from counting observations. These conditional moment equations have so far been limited to relatively simple reaction systems as their manual derivation becomes difficult for systems involving many components and interactions. Here, we present a Python tool for the automated derivation of moment equations conditional on complete time trajectories for arbitrary user-defined reaction systems and showcase its utility in the context of subnetwork simulation. With this automated tool, conditional moment equations become applicable to a broad class of biochemical systems.
Details
| Original language | English |
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| Title of host publication | Computational Methods in Systems Biology - 20th International Conference, CMSB 2022, Proceedings |
| Editors | Ion Petre, Andrei Păun |
| Publisher | Springer Science and Business Media B.V. |
| Pages | 286-293 |
| Number of pages | 8 |
| ISBN (print) | 9783031150333 |
| Publication status | Published - 2022 |
| Peer-reviewed | Yes |
Publication series
| Series | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
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| Volume | 13447 LNBI |
| ISSN | 0302-9743 |
Conference
| Title | 20th International Conference on Computational Methods in Systems Biology |
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| Abbreviated title | CMSB 2022 |
| Conference number | 20 |
| Duration | 14 - 16 September 2022 |
| Location | University of Bucharest |
| City | Bucharest |
| Country | Romania |
Keywords
ASJC Scopus subject areas
Keywords
- Conditional moments, Moment generator, Stochastic biochemical networks