Associations of Tissue and Soluble LOX-1 with Human Abdominal Aortic Aneurysm

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Background Indication for prophylactic surgical abdominal aortic aneurysm (AAA) repair depends on the maximal aortic diameter. The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for uptake of oxidized low-density lipoprotein cholesterol and is implicated in atherosclerosis. A soluble form of LOX-1 (sLOX-1) has been discussed as a novel biomarker in coronary artery disease and stroke. Herein, we assessed the regulation of aortic LOX-1 as well as the diagnostic and risk stratification potential of sLOX-1 in patients with AAA. Methods and Results Serum sLOX-1 was assessed in a case-control study in AAA (n=104) and peripheral artery disease (n=104). sLOX-1 was not statistically different between AAA and peripheral artery disease but was higher in AAA (β=1.28, P=0.04) after adjusting for age, atherosclerosis, type 2 diabetes, prescription of statins, β-blockers, ACE inhibitors, and therapeutic anticoagulation. sLOX-1 was not associated with the aortic diameter, AAA volume, or the thickness of the intraluminal thrombus. Aortic LOX-1 mRNA expression tended to be higher in AAA when compared with disease, and expression was positively associated with cleaved caspase-3, smooth muscle actin, collagen, and macrophage content. Conclusions In AAA, sLOX-1 was differently affected by age, cardiometabolic diseases, and corresponding medical therapies. Comparison with nonatherosclerotic disease would be beneficial to further elucidate the diagnostic potential of sLOX-1, although it was not useful for risk stratification. Aneurysmal LOX-1 mRNA expression was increased and positively associated with smooth muscle cells and collagen content, suggesting that LOX-1 is eventually not deleterious in human AAA and could counteract AAA rupture.


Original languageEnglish
Article numbere027537
JournalJournal of the American Heart Association
Issue number14
Early online date8 Jul 2023
Publication statusPublished - 18 Jul 2023

External IDs

unpaywall 10.1161/jaha.122.027537
Scopus 85165221099
Mendeley 45a34a94-f0fa-3b68-96e4-383dec11a79d
ORCID /0000-0001-7803-1972/work/142235127


Subject groups, research areas, subject areas according to Destatis

Sustainable Development Goals


  • Aortic Aneurysm, Abdominal/genetics, Atherosclerosis, Biomarkers, Case-Control Studies, Diabetes Mellitus, Type 2, Humans, Peripheral Arterial Disease, RNA, Messenger, Scavenger Receptors, Class E, soluble LOX-1, LOX-1, abdominal aortic aneurysm

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