Arthritis and prolactin: A phylogenetic viewpoint

Research output: Contribution to journalReview articleContributedpeer-review


  • Norma Adan - , Universidad Nacional Autónoma de México (Author)
  • Maria G. Ledesma-Colunga - , Universidad Nacional Autónoma de México (Author)
  • Ana L. Reyes-Lopez - , Universidad Nacional Autónoma de México (Author)
  • Gonzalo Martinez de la Escalera - , Universidad Nacional Autónoma de México (Author)
  • Carmen Clapp - , Universidad Nacional Autónoma de México (Author)


Arthritic disorders are family of diseases that have existed since vertebrate life began. Their etiology is multifactorial with genetic, environmental, and gender factors driving chronic joint inflammation. Prolactin is a sexually dimorphic hormone in mammals that can act to both promote and ameliorate rheumatic diseases. It is found in all vertebrate groups where it exerts a wide diversity of actions. This review briefly addresses the presence and features of arthritic diseases in vertebrates, the effects of PRL on joint tissues and immune cells, and whether PRL actions could have contributed to the ubiquity of arthritis in nature. This comparative approach highlights the value of PRL as a biologically conserved factor influencing the development and progression of arthritis. (C) 2014 Elsevier Inc. All rights reserved.


Original languageEnglish
Pages (from-to)132-136
Number of pages5
JournalGeneral and Comparative Endocrinology
Publication statusPublished - 1 Jul 2014
Externally publishedYes

External IDs

PubMed 24508497
Scopus 84906794019
ORCID /0000-0002-2061-8663/work/150329816



  • Inflammation, Osteoarthritis, Reproduction, Rheumatoid arthritis, Spondyloarthritis, Stress