Arthritis and prolactin: A phylogenetic viewpoint
Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel (Review) › Beigetragen › Begutachtung
Beitragende
Abstract
Arthritic disorders are family of diseases that have existed since vertebrate life began. Their etiology is multifactorial with genetic, environmental, and gender factors driving chronic joint inflammation. Prolactin is a sexually dimorphic hormone in mammals that can act to both promote and ameliorate rheumatic diseases. It is found in all vertebrate groups where it exerts a wide diversity of actions. This review briefly addresses the presence and features of arthritic diseases in vertebrates, the effects of PRL on joint tissues and immune cells, and whether PRL actions could have contributed to the ubiquity of arthritis in nature. This comparative approach highlights the value of PRL as a biologically conserved factor influencing the development and progression of arthritis. (C) 2014 Elsevier Inc. All rights reserved.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 132-136 |
Seitenumfang | 5 |
Fachzeitschrift | General and Comparative Endocrinology |
Jahrgang | 203 |
Publikationsstatus | Veröffentlicht - 1 Juli 2014 |
Peer-Review-Status | Ja |
Extern publiziert | Ja |
Externe IDs
PubMed | 24508497 |
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Scopus | 84906794019 |
ORCID | /0000-0002-2061-8663/work/150329816 |
Schlagworte
Schlagwörter
- Inflammation, Osteoarthritis, Reproduction, Rheumatoid arthritis, Spondyloarthritis, Stress