Anti-Vascular endothelial growth factor therapy impairs endothelial function of retinal microcirculation in colon cancer patients - an observational study
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Background: To assess acute effects of bevacizumab (anti-VEGF therapy) on cerebral microvessels and systemic cardiovascular regulation. Design and subjects: 20 consecutive patients with colorectal cancer (median age: 60.4 years, range 45.5-73.9 years) received bevacizumab intravenously (5 mg/kg) uncoupled of chemotherapy. Prior to and within the first 24 hours after bevacizumab infusion, patients were investigated for retinal endothelial function. A series of a triple 24-hour ambulatory blood pressure measurement was conducted. Retinal endothelial function was determined as flicker light-induced vasodilation. The integrity of baroreflex arc and autonomic cardiovascular control was examined by stimulatory manoeuvres.Results: Bevacizumab therapy significantly reduced the vasodilatory capacity of retinal arterioles in response to flicker light. A slight decrease in diastolic pressure and heart rate was observed after bevacizumab infusion but this was unrelated to changes in retinal function. The pressure response upon nitroglycerin was largely preserved after bevacizumab infusion. The proportion of patients with abnormal nocturnal blood pressure regulation increased under anti-angiogenic therapy. Autonomic blood pressure control was not affected by bevacizumab treatment.Conclusions: Bevacizumab acutely impairs microvascular function independent of blood pressure changes. Imaging of the retinal microcirculation seems a valuable tool for monitoring pharmacodynamic effects of bevacizumab.Trial registration: NCT ID: NCT00740168.
Details
Original language | English |
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Article number | 7 |
Journal | Experimental & translational stroke medicine : ETSM |
Volume | 5 |
Issue number | 1 |
Publication status | Published - 13 May 2013 |
Peer-reviewed | Yes |
External IDs
ORCID | /0000-0003-2465-4909/work/162346488 |
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ORCID | /0000-0002-9321-9911/work/162348653 |
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- Angiogenesis, Cerebral hemodynamics, Endothelium, Microcirculation, Nitric oxide