Antiandrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • TUD Dresden University of Technology

Abstract

Naturally occurring naringenin derivatives, known for their estrogenic activity, were tested in two independent (anti-)androgen screening assays. Using a yeast-based androgen receptor assay relatively strong antiandrogen activities were demonstrated for 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin, while the parent compound naringenin did not show recognizable antiandrogen activity. In an androgen receptor activity assay based on the analysis of prostate specific antigen (PSA) concentrations in the supernatants of treated PC3(AR)2 cells the antiandrogenic activity of 6-(1,1 -dimethylallyl)naringenin was detected at concentrations of 10(-5) M. 8-Prenylnaringenin or naringenin have no detectable antiandrogenic effect. in summary, for the first time we provide evidence of the antiandrogenic activity of 6-DMA-N in two independent model systems. In conclusion, we demonstrated the ability of prenylated naringenins not only to act via the estrogen receptor but also through the androgen receptor.

Details

Original languageEnglish
Pages (from-to)856-858
Number of pages3
JournalPlanta medica
Volume69
Issue number9
Publication statusPublished - 4 Nov 2003
Peer-reviewedYes

External IDs

Scopus 0242351903

Keywords

Keywords

  • HUMULUS-LUPULUS L., PRENYLFLAVONOIDS, FLAVONOIDS