Antiandrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Technische Universität Dresden

Abstract

Naturally occurring naringenin derivatives, known for their estrogenic activity, were tested in two independent (anti-)androgen screening assays. Using a yeast-based androgen receptor assay relatively strong antiandrogen activities were demonstrated for 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin, while the parent compound naringenin did not show recognizable antiandrogen activity. In an androgen receptor activity assay based on the analysis of prostate specific antigen (PSA) concentrations in the supernatants of treated PC3(AR)2 cells the antiandrogenic activity of 6-(1,1 -dimethylallyl)naringenin was detected at concentrations of 10(-5) M. 8-Prenylnaringenin or naringenin have no detectable antiandrogenic effect. in summary, for the first time we provide evidence of the antiandrogenic activity of 6-DMA-N in two independent model systems. In conclusion, we demonstrated the ability of prenylated naringenins not only to act via the estrogen receptor but also through the androgen receptor.

Details

OriginalspracheEnglisch
Seiten (von - bis)856-858
Seitenumfang3
FachzeitschriftPlanta medica
Jahrgang69
Ausgabenummer9
PublikationsstatusVeröffentlicht - 4 Nov. 2003
Peer-Review-StatusJa

Externe IDs

Scopus 0242351903

Schlagworte

Schlagwörter

  • HUMULUS-LUPULUS L., PRENYLFLAVONOIDS, FLAVONOIDS