Analysis of epitope spreading over an eleven-year period in a patient with systemic lupus erythematosus

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Thomas Orth - , Johannes Gutenberg University Mainz, TUD Dresden University of Technology (Author)
  • Werner Johannes Mayet - , Johannes Gutenberg University Mainz, University Medical Center Mainz , TUD Dresden University of Technology (Author)
  • Helmut Deister - , Johannes Gutenberg University Mainz (Author)
  • Sooghee Chang - , Johannes Gutenberg University Mainz (Author)
  • Marc Schmitz - , Institute for Immunology (Author)
  • Michael Bachmann - , Institute of Physiological Chemistry, Institute for Immunology, Johannes Gutenberg University Mainz (Author)

Abstract

During a period of more than eleven years serum samples of a patient with Systemic Lupus Erythematosus were collected and analyzed for anti- nuclear autoantibodies. High titer of anti-La/SS- B were detectable in all serum samples. The La/SS-B epitopes remained constant. Besides anti-La/SS - B antibodies all serum samples contained traces of anti-Ro/SS - A including anti-Ro52 and anti-Ro60 antibodies. During disease flares anti-Ro/SS-A antibodies were upregulated and anti-dsDNA antibodies appeared, thus supporting the concept of an antigen driven intermolecular epitope spreading to Ro/SS - A and dsDNA.

Details

Original languageEnglish
Pages (from-to)461-464
Number of pages4
JournalScandinavian Journal of Rheumatology
Volume27
Issue number6
Publication statusPublished - 1998
Peer-reviewedYes

External IDs

PubMed 9855219

Keywords

ASJC Scopus subject areas

Keywords

  • Autoimmunity, Epitope spreading, La/SS-B, Sjogren's syndrome, SLE, Systemic lupus erythematosus