During a period of more than eleven years serum samples of a patient with Systemic Lupus Erythematosus were collected and analyzed for anti- nuclear autoantibodies. High titer of anti-La/SS- B were detectable in all serum samples. The La/SS-B epitopes remained constant. Besides anti-La/SS - B antibodies all serum samples contained traces of anti-Ro/SS - A including anti-Ro52 and anti-Ro60 antibodies. During disease flares anti-Ro/SS-A antibodies were upregulated and anti-dsDNA antibodies appeared, thus supporting the concept of an antigen driven intermolecular epitope spreading to Ro/SS - A and dsDNA.