The practical applications of underwater optical devices, such as cameras or sensors, often suffer from widespread surface biofouling. Current antifouling techniques are primarily hindered by low efficiency, poor compatibility, as well as environmental pollution issues. This paper presents a transparent electrode coating as antifouling system of underwater optics as potential substitute for alternating current electrokinetic (ACEK)-based systems. A strong-coupling model is established to predict the Joule heating induced fluid flows and the negative dielectrophoretic (nDEP) effect for mobilizing organisms or deposited sediments on optic surfaces. The performance of the proposed antifouling system is numerically evaluated through simulations of electrostatic, fluid and temperature fields as well as trajectories of submicron particles, which is then experimentally verified and found to be in good agreement. A parametric study revealed that the degree of electrodes asymmetry is the key factor affecting the flow pattern and therefore the overall performance of the system. This ACEK-based universal strategy is expected to shed light on designing high performance and non-toxic platforms toward energy-efficient surface antifouling applications of underwater optics.